Osler-Weber-Rendu syndrome
What causes HHT?
Someone withHHT will have a faulty gene (genetic mutation) and, usually, this will have been inherited from one of their parents.
Thisgene normally provides instructions for making certain proteins found in the lining of the blood vessels. In HHT, the gene cannot produce this protein, or the protein it produces is abnormal.
You only need to have one copy of the faulty gene to develop HHT.
Medically Reviewed by a doctor on 21 Dec 2018
Introduction
NHS Choices information on hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), with links to other useful resources.
What happens in HHT?
In HHT, some of the blood vessels do not develop properly. Normally, the arteries branch off into smaller and smaller blood vessels until they reach a network of capillaries (tiny blood vessels) that
What causes HHT?
Someone withHHT will have a faulty gene (genetic mutation) and, usually, this will have been inherited from one of their parents. Thisgene normally provides instructions for making certain proteins f
What are the symptoms?
Symptoms usually start in childhood or in the teenage years. Nosebleeds Often, the first sign is developing Nosebleed . They can start at any age, often in childhood. Nosebleeds may be frequent and
How isHHT treated?
There's no cure for HHT, but there are effective treatments and life expectancy is usually very good. Some patients can be managed by their GP, and some will need to be under the care of a specialist
Information about you
If you have HHT, your clinical team may pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS). This helps scientists look for better ways t
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