Causes of stomach cancer

Stomach cancer is caused by changes in the cells of the stomach, although it's unclear exactly why these changes occur.

Cancer begins with a change (mutation) in the structure of the DNA in cells, which can affect how they grow. This means cells grow and reproduceuncontrollably, producing a lump of tissue called a tumour.

Left untreated, cancer can spread to other parts of the body, usually through the lymphatic system (a network of vessels and glands called lymph nodes located throughout the body).

Once the cancer reaches your lymphatic system, it's capable of spreading to other parts of your body, including your blood, bones and organs.

It's not known what triggers thechanges in DNAthat lead to stomach cancer and why only a small number of people develop the condition.

Increased risk

However, evidence suggests that a number of different factors can affect yourchances of developing stomach cancer. These are discussed below.

Age and gender

Your risk of developing stomach cancer increases with age. Most cases occur in people aged 55 or over.

For reasons that are unclear, men are twice as likely as women to develop stomach cancer.

Smoking

People who smoke are about twice as likely to develop stomach cancer compared with non-smokers. This is because you swallow some cigarette smoke when you inhale and it ends up in your stomach. Cigarettes containharmful chemicals which can damage the cells in your stomach.

The more you smoke and the longer you've been smoking, the bigger the risk.In the UK, around 1in every 5 cases of stomach cancer (20%) is thought to be caused by smoking.

H. pylori infection

Helicobacter pylori (H. pylori)is a common type of bacteria. In most people, these bacteria are harmless, butin some people an H. pylori infection can cause problems such as Ulcer, peptic , recurring bouts of indigestion orlong-term inflammation of the stomach lining (chronic atrophic gastritis ).

Research has foundpeople with severe chronicatrophic gastritis havean increasedrisk of developing stomach cancer, although this risk is still small.

Diet

A diet rich in pickled vegetables, such as pickled onions or piccalilli, salted fish, salt in general and smoked meats, such as pastrami or smoked beef, increases your risk of stomach cancer.

Countries where this type of diet is popular, such as Japan, tend to have much higher rates of stomach cancer than the UK.

A high fibre diet with five portions of fruit and vegetables a day will help protect against stomach cancer, and a diet high in fats and processed food and red meat will increase your risk of getting stomach cancer.

Family history

You're more likely to develop stomach cancer if you have a close relative with the condition, such as one of your parents or a sibling (brother or sister). In such cases, it may be appropriate for your doctor to arrange genetic counselling .

It's not fully understood why stomach cancer seems to run in families. It may be because of shared risk factors, such as having similar diets or having an H. pylori infection, or because of certain genes you inherit from your parents.

In around one in 50 cases of stomach cancer, testing has found that people share a mutation in a gene known as E-cadherin.

Research into stomach cancer has also shown that you may be more at risk of getting the condition if you have the blood type A. Your blood type is passed on from your parents, so this could be another way in which family history may increase your risk of developing stomach cancer.

There's also a condition that runs in families called familial adenomatous polyposis (FAP), which may increase your risk of developing stomach cancer. FAP causes small growths, called polyps, to form in your digestive system, and is known to increase your risk of developing bowel cancer .

Having another type of cancer

Your risk of developing stomach cancer is increased if you've had another type of cancer, such as cancer of the oesophagus or non-Hodgkin lymphoma (cancer that develops in your white blood cells).

For men, the risk of getting stomach cancer is increased after having prostate cancer , bladder cancer , breast cancer or testicular cancer . For women, the risk of developing stomach cancer increases after having ovarian cancer , breast cancer or cervical cancer .

Certain medical conditions

Having certain medical conditions can also increase your risk of developing stomach cancer, such as pernicious anaemia (a vitamin B12 deficiency, which occurs when your body can't absorb it properly), and peptic stomach ulcers (an ulcer in your stomach lining, often caused by H. pylori infection).

Stomach surgery

If you've had stomach surgery, or surgery to a part of your body that affects your stomach, you may be more likely to develop stomach cancer.

This can include surgery to remove part of your stomach (known as a partial gastrectomy ), surgery to remove part of your vagus nerve (the nerve that carries information from your brain to organs such as your heart, lungs and digestive system), or surgery to repair a stomach ulcer.

How stomach cancer spreads

There are three ways stomach cancer can spread:

• directly the cancer can spread from the stomach into nearby tissues and organs, such as the pancreas, colon, small intestine and peritoneum (the lining of the inside of the abdominal cavity)
• throughthe lymphatic system the lymphatic system is a series of glands (nodes) located throughout your body, similar to the blood circulatory system; the glands produce specialised cells needed by your immune system to fight infection
• throughthe blood which can cause the cancer to spread from the stomach to other parts of the body, most commonly the liver

Stomach cancer that spreads to another part of the body is known as metastatic stomach cancer.