Wegeners Granulomatosis
How GPA is diagnosed
Source: NHS
In this topic (9)
Your doctor may suspect GPA if you feel unwell, have a persistent fever and have lost weight, and one or more of the following areas of your body is affected:
- your nose, ears and sinuses for example, you have persistent earache , nosebleeds or sinusitis
- lungs for example, you have difficulty breathing or are coughing up blood, or your chest X-ray shows lung abnormalities
- kidneys for example, there is blood or protein in your urine
Blood tests may be done to test levels of ANCAs (antineutrophil cytoplasmic antibodies). These are antibodies thought to be involved in the process that leads to the blood vessels becoming inflamed.
However, this test can sometimes come back negative in people with GPA and positive in people who dont have the condition, so it can't be relied upon on its own to diagnose the condition.
A tissue sample of the affected area may also be removed (a biopsy ) and looked at under the microscope for evidence of inflammation. In GPA, white blood cells clump together to form tiny lumps called granulomas.
Computerised tomography (CT) scans and magnetic resonance imaging (MRI) scans may also be carried out to assess the condition of any organs or areas of the body that may be affected.
Articles for Wegeners Granulomatosis
How GPA is diagnosed
Your doctor may suspect GPA if you feel unwell, have a persistent fever and have lost weight, and one or more of the following areas of your body is affected: your nose, ears and sinuses for examp
HowGPA istreated
The aim of treatment for GPA is firstly to bring the condition under control (known as inducing remission), and then try to prevent the condition relapsing (known as maintaining remission). For most
Information about you
If you have GPA, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS). This helps scientists look for better ways
Introduction
Granulomatosis with polyangiitis (GPA) is a rare disease which causes the walls of the blood vessels to become inflamed (swollen).
Outlook
Although GPA can be life-threatening, early diagnosis and modern treatments can significantly improve the outlook. Most people are able to achieve remission with medical treatment, although about hal
Signs and symptoms
The inflammation of the blood vessels (known as vasculitis) caused by GPA mainly affects the nose, sinuses, ears, lungs and kidneys, although other organs can be affected too, including the brain, ski
What causes GPA?
The exact cause of GPA is unknown. It is thought that GPA is likely to be an autoimmune disease, which means the body's immune system mistakenly attacks its own tissues. As with other autoimmune diso
When to seek medical advice
If you have any of the above symptoms that are persistent or troublesome see your GP. They can arrange appropriate tests if they suspect GPA is the cause and, if appropriate, arrange referral to a spe
Who is affected
Around 500 men and women are diagnosed with GPA each year in the UK. Symptoms can start at any age, including in childhood, although the condition usually first appears in middle-aged or elderly peop
