Wegeners Granulomatosis
Signs and symptoms
Source: NHS
In this topic (9)
The inflammation of the blood vessels (known as vasculitis) caused by GPA mainly affects the nose, sinuses, ears, lungs and kidneys, although other organs can be affected too, including the brain, skin, nerves, heart and bowels.
This means the condition can have a wide range of symptoms, such as:
- a persistent unexplained fever
- Night sweats
- fatigue (extreme tiredness) and weakness
- a general ill feeling
- loss of appetite and weight loss
- joint pain and soreness
- persistent ear infections and reduced hearing
- frequent sinusitis
- recurrent nosebleeds and crusts around the nose
- chest pain , cough and shortness of breath
- coughing up blood or blood in the phlegm
- blood in the urine
Some people with GPA may also be at risk of developing blood clots in their legs ( deep vein thrombosis ) or lungs ( pulmonary embolism ).
Articles for Wegeners Granulomatosis
How GPA is diagnosed
Your doctor may suspect GPA if you feel unwell, have a persistent fever and have lost weight, and one or more of the following areas of your body is affected: your nose, ears and sinuses for examp
HowGPA istreated
The aim of treatment for GPA is firstly to bring the condition under control (known as inducing remission), and then try to prevent the condition relapsing (known as maintaining remission). For most
Information about you
If you have GPA, your clinical team will pass information about you on to the National Congenital Anomaly and Rare Diseases Registration Service (NCARDRS). This helps scientists look for better ways
Introduction
Granulomatosis with polyangiitis (GPA) is a rare disease which causes the walls of the blood vessels to become inflamed (swollen).
Outlook
Although GPA can be life-threatening, early diagnosis and modern treatments can significantly improve the outlook. Most people are able to achieve remission with medical treatment, although about hal
Signs and symptoms
The inflammation of the blood vessels (known as vasculitis) caused by GPA mainly affects the nose, sinuses, ears, lungs and kidneys, although other organs can be affected too, including the brain, ski
What causes GPA?
The exact cause of GPA is unknown. It is thought that GPA is likely to be an autoimmune disease, which means the body's immune system mistakenly attacks its own tissues. As with other autoimmune diso
When to seek medical advice
If you have any of the above symptoms that are persistent or troublesome see your GP. They can arrange appropriate tests if they suspect GPA is the cause and, if appropriate, arrange referral to a spe
Who is affected
Around 500 men and women are diagnosed with GPA each year in the UK. Symptoms can start at any age, including in childhood, although the condition usually first appears in middle-aged or elderly peop
