Introduction

Jaundice is a term used to describe the yellowing of the skin and the whites of the eyes.

It's caused by a build-up of a substance called bilirubin in the blood and body's tissues.

Signs of jaundice

The most common signs of jaundice are:

• yellowing of the skin, eyes and the lining of the inside of parts of the body, such as the mouth and nose (mucus membrane)
• pale-coloured stools
• dark-coloured urine

When to seek medical advice

Always seek immediate medical advice if you develop the above signs of jaundice. They're a warning sign that something is wrong with the normal processes of your body.

Speak to your GP as soon as possible. If this isn't possible, telephone NHS111 or contact your local out-of-hours service .

Types of jaundice

There are threetypes of jaundice depending on what's disrupting the normal removal of bilirubin from the body. They are:

• pre-hepatic jaundice the disruption happens before bilirubin has been transported from the blood to the liver; it's caused by conditions such as Sickle cell anaemia and haemolytic anaemia
• intra-hepatic jaundice (also known as hepatocellular jaundice) the disruption happens inside the liver; it's caused by conditions such as Gilbert's syndrome , cirrhosis or other liver damage
• post-hepatic jaundice (also known as obstructive jaundice) the disruption prevents the bile (and the bilirubin inside it) from draining out of the gallbladder and into the digestive system; it's caused by conditions such as gallstones or tumours

Pre-hepatic jaundice can affect people of all ages, including children.

Certain lifestyle changes may help prevent jaundice. For example, maintaining a healthy weight , not drinking too much alcohol , and minimising your risk of hepatitis , will all help.

Diagnosing jaundice

If you have jaundice, you'll have a number of tests to find out how severe it is and determine the underlying cause.

You'll probably have a urine test and liver function and blood tests . If intra-hepatic jaundice or post-hepatic jaundice is suspected, it's often possible to confirm the diagnosis using imaging tests to check for abnormalities inside the liver or bile duct systems.

This may involve treating the underlying condition, a blood transfusion or surgery.

These include:

• ensuring you don't exceed the recommended daily amount (RDA) for alcohol consumption
• maintaining a healthy weight for your height and build
• if appropriate, ensuring you're vaccinated against hepatitis A or hepatitis B if you're travelling to high-risk areas of the world
• minimising your risk of exposure to hepatitis C because there's currently no vaccine for the condition; In England, the most effective way of preventing hepatitis C is by not injecting illegal drugs , such as heroin, or making sure that you don't share drug injecting equipment if you do