Taking paracetamol with other medicines

Paracetamol can react unpredictably with certain other medications. This can affect how well either medicine works and might increase the risk of side effects.

It may not be safe to take paracetamol at the same time as:

  • other products containing paracetamol – including combination products where paracetamol is one of the ingredients
  • carbamazepine – used to treat epilepsy and some types of pain
  • colestyramine – used to reduce itchiness caused by primary biliary cirrhosis (a type of liver disease)
  • imatinib and busulfan – used to treat certain types of cancer
  • ketoconazole – a type of antifungal medicine
  • lixisenatide – used to treat type 2 diabetes
  • metoclopramide – used to relieve nausea and vomiting
  • phenobarbital, phenytoin and primidone – used to control seizures
  • warfarin – used to prevent blood clots

Check the leaflet that comes with your medicine to see if it can be taken with paracetamol. Ask a pharmacist or doctor if you're not sure.

There are no known problems caused by taking paracetamol with any specific foods or by drinking moderate amounts of alcohol while taking paracetamol.

Content supplied by the NHS Website

Medically Reviewed by a doctor on 20 Feb 2018