Paracetamol

Taking paracetamol with other medicines

Paracetamol can react unpredictably with certain other medications. This can affect how well either medicine works and might increase the risk of side effects.

It may not be safe to take paracetamol at the same time as:

other products containing paracetamol – including combination products where paracetamol is one of the ingredients
carbamazepine – used to treat epilepsy and some types of pain
colestyramine – used to reduce itchiness caused by primary biliary cirrhosis (a type of liver disease)
imatinib and busulfan – used to treat certain types of cancer
ketoconazole – a type of antifungal medicine
lixisenatide – used to treat type 2 diabetes
metoclopramide – used to relieve nausea and vomiting
phenobarbital, phenytoin and primidone – used to control seizures
warfarin – used to prevent blood clots

Check the leaflet that comes with your medicine to see if it can be taken with paracetamol. Ask a pharmacist or doctor if you're not sure.

There are no known problems caused by taking paracetamol with any specific foods or by drinking moderate amounts of alcohol while taking paracetamol.

Medically Reviewed by a doctor on 20 Feb 2018

Articles for paracetamol

Introduction

Paracetamol is a commonly used medicine that can help treat pain and reduce a high temperature (fever). It is often recommended as one of the first treatments for pain, as it's safe for most people to take and side effects are rare.

Taking paracetamol with other medicines

Paracetamol can react unpredictably with certain other medications. This can affect how well either medicine works and might increase the risk of side effects.

Side effects of paracetamol

Side effects from paracetamol are rare, but can include: an allergic reaction, flushing, low blood pressure, blood disorders, liver and kidney damage if you take too much. Speak to a pharmacist or doctor if you develop any troublesome side effects.

Overdoses of paracetamol

Taking too much paracetamol, known as an overdose, can be very dangerous. If you've taken more than the recommended maximum dose, go to your nearest accident and emergency (A&E) department as soon as possible.

Who can take paracetamol?

Most people can take paracetamol safely, including: pregnant women, breastfeeding women, children over 2 months of age (lower doses are recommended for young children). Always get advice before taking paracetamol.

How should I take paracetamol?

Make sure you take paracetamol as directed on the label or leaflet, or as instructed by a health professional. How much you can take depends on your age, your weight, the type of paracetamol you're taking and how strong it is.

Can I take paracetamol and ibuprofen together?

If you're 16 or over, it's safe to take paracetamol and ibuprofen together as there are no known harmful interactions between these medicines. The advice for children is different.

Can I give my child paracetamol and ibuprofen at the same time?

No, don't give your child paracetamol and ibuprofen at the same time, unless advised to by a healthcare professional. If you give them one of these medicines and they're still distressed before the next dose is due, you could try the other medicine instead.

Can I take paracetamol or ibuprofen with cough or cold medicines?

It depends whether the cough or cold medicine also contains paracetamol or ibuprofen. Avoid exceeding the maximum dose, you should not take paracetamol or ibuprofen if you're already taking a cough or cold medicine that contains these ingredients.

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