Peripheral arterial disease


There's no cure for peripheral arterial disease (PAD), but lifestyle changes and medication can help reduce the symptoms.

These treatments can also help reduce your risk of developing other types of cardiovascular disease (CVD) , such as:

This is very important, because having PAD is a sign that your blood vessels are unhealthy. This could mean you're more likely to develop one of these potentially more serious problems.

Surgery may be used in severe cases or when initial treatment hasn't effectively reduced your symptoms.

Lifestyle changes

The two most important lifestyle changes that you can make if you're diagnosed with PAD are exercising more regularly and stopping smoking, if you smoke.


Evidence suggests that regular exercise helps to reduce the severity and frequency of PAD symptoms, while also reducing the risk of developing another CVD.

The National Institute for Health and Care Excellence (NICE) recommends supervised exercise as one of the first steps for managing PAD. This may involve group exercise sessions with other people with CVD,led by a trainer.

The exercise programme usually involves two hours of supervised exercise a week for three months. Ideally, over time, you should be aiming to exercise daily for the rest of your life, as the benefits of exercise are quickly lost if it's not frequent and regular.

One of the best exercises you can do is walking. It's normally recommended that you walk as far and as long as you can before the symptoms of pain become intolerable. Once this happens, rest until the pain goes, and begin walking again until the pain returns.

Keep using this "stop-start" method until you've spent at least 30 minutes walking in total. This should ideally be repeated severaltimes a week.

You'll probably find the exercise course challenging, as the frequent episodes of pain can be upsetting and off-putting. However, if you persevere, you should gradually notice a marked improvement in your symptoms, and you'll begin to go longer periods without experiencing pain.

Read about:

Getting started with exercise

Health and fitness

Walking for health

Stop smoking

Stoppingsmoking will reduce your risk of PAD getting worse and another serious CVD developing.

Research has found that people who continue to smoke after receiving their diagnosis are much more likely to have a heart attack anddie from a complication of heart disease than people who quit after receiving their diagnosis.

They help to reduce the amount of water in your blood and widen your arteries, both of which decrease your blood pressure.

Side effects of ACE inhibitors include:

  • dizziness
  • tiredness or weakness
  • headaches
  • a persistent dry cough

Most of these side effectspass in a few days, although some people findthey have a dry cough a bit longer.

If your side effects become particularly troublesome, a medication that works in a similar way to ACE inhibitors, known as an angiotensin-2 receptor antagonist, may be recommended.

This can cause a blood clot to develop at the site of the broken plaque.

If a blood clot develops inside an artery that supplies the heart with blood (a coronary artery), it can trigger a heart attack. Similarly, if a blood clot develops inside any of the blood vessels going to the brain, it can trigger a stroke.

If you have PAD, you'll probably be prescribed an antiplatelet medication to reduce your risk of blood clots. This medication reduces the ability of platelets (tiny blood cells) to stick together, so if a plaque does break apart, you have a lower chance of a blood clot developing.

Low-dose aspirin and clopidogrel are two antiplatelet medications often prescribed for people with PAD.

Common side effects of low-dose aspirin include indigestion and an increased risk of bleeding.

Common side effects of clopidogrel can include:

  • headaches or dizziness
  • feeling sick
  • diarrhoea or constipation
  • indigestion
  • stomach (abdominal) pain
  • an increased risk of bleeding

Naftidrofuryl oxalate

NICE recommends naftidrofuryl oxalate for the treatment of leg pain triggered by exercise (intermittent claudication)in people with PAD.

This medication may improve blood flow in the body, and is very occasionally used if you prefer not to have surgery or your supervised exercise programme hasn't led to a satisfactory improvement in your condition.

Side effects of naftidrofuryl oxalate can include:

  • feeling sick
  • abdominal pain
  • diarrhoea
  • rashes

You'll normally be advised to take naftidrofuryl oxalate for around three to six months, to see if it improves your symptoms. If the treatment isn't effective after this time, it will be stopped.

Surgery and procedures

In a few cases, a procedure to restore the flow of blood through the arteries in your legs may be recommended. This is known as revascularisation.

Revascularisation may be recommended if your leg pain is so severe it prevents you from carrying out everyday activities,or if your symptoms have failed to respond to the treatmentsmentioned above.

There are two main types ofrevascularisation treatment for PAD:

  • angioplasty where a blocked or narrowed section of artery is widened by inflating a tiny balloon inside the vessel
  • artery bypass graft whereblood vessels are taken from another part of your body and used to bypass the blockage in an artery

Which procedure is best?

You may not always be able to choose between having anangioplasty or a bypass graft, but if you are, it's important to be aware of the advantages and disadvantages of each technique.

An angioplasty is less invasive than a bypass it doesn't involve making major cuts (incisions) in your body andis usually performed under local anaesthetic as a day procedure. This means you'll be able to go home the same day you have the operation, and you may recover more quickly.

For this reason, angioplasty is generally preferred to bypass surgery, unless angioplasty isn't suitable or has failed previously.

However, the results of a bypass are generally considered to be longer-lastingthan those of an angioplasty, and the procedure may need to be repeatedless often than an angioplasty.

Both angioplasty and bypass surgery carry a small risk of serious complications, such as a heart attack, stroke and even death. While there are few studies comparing the two techniques for PAD, there's some evidence to suggest that the risk of serious complications is similar in both bypass surgery and angioplasty.

Before recommending treatment, a team of specialist surgeons, doctors and nurses will discuss options with you including the potential risks and benefits.

Content supplied by the NHS Website

Medically Reviewed by a doctor on 26 Oct 2016