As most cases of vitamin B12 deficiency or folate deficiency can be easily and effectively treated, complications are rare.

However, complications can occasionally develop, particularly if you've been deficientin either vitaminfor some time.

Anaemia complications

All types of anaemia, regardless of the cause, can lead to heart and lung complications as the heart struggles to pump oxygen to the vital organs.

Adults with severe anaemia are at risk of developing:

  • an abnormally fast heart beat(tachycardia)
  • heart failurewhere the heart fails to pump enough blood around the body at the right pressure

Complications of vitamin B12 deficiency

A lack of vitamin B12 (with or without anaemia) can cause the following complications:

Neurological changes

A lack of vitamin B12 can cause neurological problems (issues affecting your nervous system), such as:

  • vision problems
  • memory loss
  • pins and needles (paraesthesia)
  • loss of physical coordination (ataxia), which can affect your whole body and cause difficulty speaking or walking
  • damage to parts of the nervous system (peripheral neuropathy), particularly in the legs

If neurological problems do develop, they may be irreversible.


Vitamin B12 deficiency can sometimeslead to temporary infertility (an inability to conceive). Thisusually improves with appropriate vitamin B12 treatment.

Stomach cancer

If you have a vitamin B12 deficiency caused by pernicious anaemia (a condition where your immune system attacks healthy cells in your stomach), your risk of developing stomach cancer is increased.

Neural tube defects

If you're pregnant, not having enough vitamin B12 can increase the risk of your baby developing a serious birth defect known as aneural tube defect. The neural tube is a narrow channel that eventuallyforms the brain and spinal cord.

Examples of neural tube defects include:

  • spina bifidawhere the baby's spine doesn't develop properly
  • anencephalywherea baby is born without parts of the brain and skull
  • encephalocelewhere a membrane or skin-covered sac containing part of the brain pushes out of a hole in the skull

Complications of folate deficiency

A lack of folate (with or without anaemia) can also cause complications, some of which are outlined below.


As with a lack of vitamin B12, a folate deficiency can also affect your fertility. However,this is only temporary and can usually be reversedwith folate supplements.

Cardiovascular disease

Research has showna lack of folate in your body may increase your risk ofcardiovascular disease (CVD).

CVD is a general term that describes a disease of the heart or blood vessels, such ascoronary heart disease (CHD).


Research has shown that folate deficiency can increase your risk of some cancers, such ascolon cancer.

Problems in childbirth

Alack of folate during pregnancy may increase the risk of the baby being born prematurely (before the 37th week of pregnancy) or having a low birthweight.

The risk ofplacental abruption may also be increased. Thisis a serious condition where the placenta starts to come away from the inside of the womb wall, causingtummy (abdominal) pain and bleeding from the vagina.

Neural tube defects

As with a vitamin B12 deficiency, a lack of folate can also affect an unborn baby's growth and development in the womb (uterus). This increases the risk of neural tube defects such as spina bifida developing in the unborn baby.

Content supplied by the NHS Website

Medically Reviewed by a doctor on 30 Nov 2016