Causes of Crohn's disease

The exact cause of Crohn's disease is unknown. Most researchers think it's caused by a combination of factors.

These are thought to be:

  • genetics
  • the immune system
  • smoking
  • previous infection
  • environmental factors

There's no evidence to suggest a particular diet can cause Crohn's disease, although dietary changes can control certain symptoms and may be recommended by your specialist or dietitian.

Read abouttreatment for Crohn's disease for more information.


There's evidence to suggest genetics plays a role in the development of Crohn's disease.

Researchers have identifiedmore than200 different genes that are more common in people with Crohn's disease than in the general population.

There's also evidence that Crohn's disease canrun in families. About 3 in 20 people with the condition have a close relative (mother, father, sister or brother) who also has Crohn's disease. For example, if you have an identical twin with the condition, you have a 70% chance of developing it.

The fact that Crohn's disease is more common in some ethnic groups than in others also suggests that genetics plays an important role.

The immune system

The immune system provides protection against harmful bacteria that could potentially find their way into the digestive system.

The digestive system is also home tomany different types of so-called "friendly bacteria" that help to digest food. The immune systemusually recognises these bacteria and lets them do their job without attacking them.

However, in Crohn's disease, it seems that something disrupts the immune system, which sends a special protein known as tumour necrosis factor-alpha (TNF-alpha) to killall bacteria, regardless of whether they're friendly or not. This causesmost of the inflammation associated with Crohn's disease.

Previous infection

In certain genetically susceptible individuals, a previous childhood infection may lead to an abnormal immune response, causing the symptoms of Crohn's disease.


Aside from family history and ethnic background, smoking is the most important risk factor for Crohn's disease. Smokers are twice as likely to develop the condition than non-smokers.

Furthermore, people with Crohn's disease who smoke usually experience more severe symptoms and are much more likely to require surgery.

Read about how to get helpto stop smoking.

Environmental factors

There are two unusual aspects of Crohn's disease that have led many researchers to believe that environmental factors may play a role. These are explained below:

  • Crohn's disease is a "disease of the rich". The highest number of cases occurs in developed parts of the world, such as the UK and the US, and thelowest number occur in developing parts of the world, such as Africa and Asia.
  • Crohn's disease became much more widespread from the 1950s onwards.

This suggests there is somethingassociated with modern Western lifestyles that increases a person's risk of developing the condition.

One theory to explain this is known as the hygiene hypothesis. It suggests that as children grow up in increasingly germ-free environments, their immune system doesn't fully developbecause ofa lack of exposure to childhood infections. However, there's little in the way of hard scientific evidence to support this theory.

An alternative theory is the cold-chain hypothesis, which suggests that the increase in Crohn's disease cases might be linked to the increased use of refrigerators after the Second World War.

Content supplied by the NHS Website

Medically Reviewed by a doctor on 28 Nov 2016